The present study deals with the development of an accurate, economical and reproducible UV spectrophotometric method simultaneous estimation of lamivudine, efavirenz and zidovudine. The method employs formation and solving of simultaneous equation using 246.2, 265.8 and 269.6 nm as three analytical wavelengths. The drugs obey Beer’s law in the concentration ranges of 3-21 µg/ml. Accuracy and reproducibility of the proposed method was statistically validated by recovery studies. The method was found to be rapid, precise and accurate and can easily be employed in the laboratory for the routine estimation of drugs.
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